Magnetic Particle Spectroscopy for the Detection of Influenza A Virus Subtype H1N1

Sunday, March 22, 2020 - 7:30pm

Congratulations to Dr. Kai Wu and the co-authors. Their join work "Magnetic Particle Spectroscopy for Detection of Influenza A Virus Subtype H1N1" is publisehd in ACS Appl. Mater. Interfaces.

In this work, they introduced a new biosensing scheme based on magnetic particle spectroscopy (MPS) and the self-assembly of MNPs to quantitatively detect H1N1 nucleoprotein molecules. The H1N1 nucleoprotein molecule hosts multiple different epitopes that forms binding sites for many IgG polyclonal antibodies. Anchoring IgG polyclonal antibodies onto MNPs triggers the cross-linking between MNPs and H1N1 nucleoprotein molecules, thereby forming MNP self-assemblies. Using MPS and the self-assembly of MNPs, we were able to detect as low as 44 nM (4.4 pmole) H1N1 nucleoprotein.